For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29. induced loss of LZIP function correlates with cellular transformation. This manual is for Lzip (version 1.23, 24 January 2022). S-score therefore represents the relative target specificity of a MAb to its intended target a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. element binding (CREB), activating transcription factor 2 (ATF-2), Oct-1 and TATA. If targets on HuProt TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt TM array. DNA-Binding: sequence-specific LZIP appears to be a transcription factor that. The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. Analysis of protein array containing more than 19,000 full-length human proteins using Anti-OVOL2 Antibody. A protein containing ATF2 fused to the GAL4 DNA-binding domain activates a.
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